Heating an unheated suspension of Salmonella Typhi typically produces agglutination of Vi antisera. After heating, agglutination will occur in which grouping sera?

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Multiple Choice

Heating an unheated suspension of Salmonella Typhi typically produces agglutination of Vi antisera. After heating, agglutination will occur in which grouping sera?

Explanation:
Antigen exposure on the bacterial surface determines which antisera can cause agglutination. Salmonella Typhi carries a Vi capsule that can mask the underlying somatic (O) antigens. Heating disrupts this capsule, revealing the O antigen that corresponds to serogroup D. Because Typhi’s O antigen is in serogroup D, sera targeting that specific O antigen will now recognize and agglutinate the cells. In other words, after heating, the grouping sera for the group D O antigen will produce agglutination.

Antigen exposure on the bacterial surface determines which antisera can cause agglutination. Salmonella Typhi carries a Vi capsule that can mask the underlying somatic (O) antigens. Heating disrupts this capsule, revealing the O antigen that corresponds to serogroup D. Because Typhi’s O antigen is in serogroup D, sera targeting that specific O antigen will now recognize and agglutinate the cells. In other words, after heating, the grouping sera for the group D O antigen will produce agglutination.

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